Kresnantio, Febryan Fadhil and Damayanti, Galih Sari and Puruhito, Buwono and Widyawati, Widyawati (2025) The Effect of Application of Clitoria ternatea Extract Cream on Level of IL-6: Experimental Study on Male Wistar Rats Induced with UVB Rays. Undergraduate thesis, Universitas Diponegoro.

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Abstract

Background: UVB exposure possesses the ability to cause complaints in the skin such as redness (erythema) accompanied with itching and pain. Redness of the skin could trigger inflammatory mediators in the skin such as IL-6, IL-10, and TNF-a. Butterfly pea (Clitoria ternatea) has the potential to be a potent antioxidant and anti- inflammatory due to its flavonoid, polyphenol, and anthocyanin content. Aim: Analyse the effect of giving butterfly pea flower cream extract to Wistar rats exposed to UVB on Interleukin-6 (IL-6) levels. Method: This research is true experimental Post test Only Group Design with simple random sampling as a sampling method. Research samples are
male wistar rats that will be under UVB exposure and applied Clitoria ternatea extract cream for 3 days weekly for one month. IL-6 analyses uses ELISA kit in the GAKI Laboratorium in Diponegoro Hospital Results: Sample was collected from 40 male wistar rats which were divided into 5 groups based on Clitoria ternatea cream formulation, base cream group, and control group. P3 group with Clitoria ternatea extract 5% cream had the lowest IL-6 levels compared to the other group. No significant difference between the Clitoria ternatea extract group, control, and base cream (P value= 0.203, P value significant < 0.05). Conclusion: Application of Clitoria ternatea cream extract does not effect the level of IL-6 in male wistar exposed to UVB rays.

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