Suprapto Putro, Raden Bayu Aji Nugroho and HAFIZ, ALINI (2024) DOCOSAHEXAENOIC ACID (DHA) DENGAN KEJADIAN PARTUS PREMATURUS (Studi pada Ibu Hamil di RSUP Dr. Kariadi dan Lahan Jejaring tahun 2024). Masters thesis, Universitas Diponegoro.

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Abstract

Introduction: Preterm labor accounts for 75% of perinatal deaths. Infection and activation of the inflammatory response driven by infection are considered major risk factors for spontaneous preterm labor. DHA as a precursor of docosanoids (resolvins, maresins) has anti-inflammatory properties and protects individuals from inflammation.
Aim: Analyzing the relationship between serum DHA levels and the incidence of premature birth.
Method: The croos sectional study involved 40 pregnant women with preterm labor between >20 - <37 weeks of gestation and 40 normal pregnant women with gestation between >20 - <37 weeks of gestation. Evaluation was conducted on maternal venous blood DHA levels obtained within <24 hours after delivery. Analysis was conducted using the Independent T-test, Mann Whitney U, Chi-square and Fisher exact tests with a significance of p<0.05.
Result: DHA levels of preterm labor subjects had an average of 82.32 ± 60.05 μg/mL while normal subjects had an average of 117.61 ± 85.55 μg/mL with a significant difference between study groups (p = 0.004). ROC curve analysis (AUC 0.688, p = 0.002) of DHA levels obtained a cut off of <89.07 μg/mL with a sensitivity of 70% and a specificity of 62.5%. Pregnant women with DHA levels <89.07 μg/mL had a 2x higher risk (RR 2.00; 95% CI: 1.20-3.35; p = 0.04) of experiencing preterm labor compared to pregnant women with DHA levels >89.07 μg/mL.
Conclusion: Evaluation of DHA levels during pregnancy can be used as a predictor of the incidence of premature birth.

Keywords: Diagnostic accuracy, DHA, preterm labor

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