Firdausya1, Maulida Nur and Noer, Etika Ratna and Purwanti, Rachma and Nuryanto, Nuryanto Correlation of Serum Magnesium with HbA1c Levels and Lipid Profiles on Type 2 Diabetes Mellitus Patients in Semarang City. -. (Unpublished)

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Abstract

Background: Type 2 diabetes mellitus identified by impaired insulin secretion and resistance is a major health problem associated with magnesium deficiency. Magnesium has an important role in insulin secretion and homeostasis as well as cofactor in glucose and lipoprotein metabolism. This study aimed to determine the relationship between serum magnesium with HbA1c levels and lipid profiles of patients with type 2 diabetes mellitus in Semarang City.
Methods: This study was conducted between August – September 2021 using cross sectional method in subjects with type 2 diabetes mellitus aged 45-65 years and taken by purposive sampling method. Data included subject’s identity, food intake during the past month assessed by SQFFQ (Semi-Quantitative Food Frequency Questionnaire), 24 hours physical activity measured by PAL (Physical Activity Level), anthropometry for height measured by microtoise and BMI measured by BIA (Bioelectrical Impedance Analyzer) TANITA, and serum magnesium measured by photometric method using xylidyl blue reagent, while HbA1c and lipid profiles levels measured by indico clinical chemistry analyzer. Data analyzed by pearson product moment, spearman’s rank, and chi-square, then continued by Multivariate Analysis of Covariance (MANCOVA).
Results: A total of 49 (89,1%) subjects with type 2 diabetes mellitus had magnesium deficiency. There’s correlation between energy intake with magnesium deficiency (p = 0,046). There’s correlation between magnesium intake with serum magnesium (r = 0,422; p = 0,001). There’s correlation between serum magnesium with HDL levels (R squared = 0,987; p = 0,013). There’s correlation between carbohydrate (r = 0,375; p = 0,005) and fat intake (r = 0,379; p = 0,004) with HbA1c levels. There’s no correlation between serum magnesium with HbA1c, cholesterol total, triglycerides, and LDL levels (p>0,05).
Conclusion: There’s correlation between magnesium serum and HDL levels. There’s no correlation between serum magnesium with HbA1c, cholesterol total, triglycerides, and LDL levels on type 2 diabetes mellitus patients in Semarang City.
Keywords: Type 2 diabetes mellitus, serum magnesium, HbA1c, lipid profiles

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