Sirait, Reynold Christian and Nugroho, Eriawan and Lestari, Endang Sri (2022) Efektivitas Ekstrak Biji Kapulaga (Amomum compactum) terhadap Kadar Malondyaldehide, Histopatologi, dan Berat Testis Tikus Obesitas. Masters thesis, Universitas Diponegoro.

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Abstract

BACKGROUND: In men, obesity is associated with low testosterone levels. In massively obese individuals, reduced spermatogenesis and associated with infertility. One of infertility mechanism due to high of ROS in obesity. A recent study found that cardamom seeds could help improve health due to their anti-inflammatory and antioxidant properties. AIM: To analyze the effects of cardamom seeds (A. compactum) on malondialdehyde, histopathology and testicle weight of wistar rats induced obesity. METHODS: This research was a true experimental with post-test only control group design with 30 wistar rats were randomly divided into five groups. Control group (KN), Negative control group (K-), and Treatment groups (obesity + cardamom 45 mg/kgBW/day) P1, (obesity + cardamom 90 mg/kgBW/day) P2, (obesity + cardamom 180 mg/kgBW/day) P3. Obesity induced by given high fat and carbohydrates diet. On day 45, termination began, testicle and blood sample were taken for examination. Testicle samples were weighed and stained using Hematoxylin Eosin stains. RESULTS: There were significant differences in histopathology Johnsen score, MDA level and testicle weight between groups K- and P1; P2; P3 (p<0.05). There were significant differences in MDA level and testicle weight between groups P1; P2; P3 (p<0.05). There were no significant differences in Johnsen's histopathology between groups P1; P2; P3. The higher dose of cardamom seeds gave better Johnsen score, MDA and testis weight. CONCLUSION: The cardamom extract seeds can prevent testicle destruction by antioxidant function and lowering MDA level in obesity rats subject.

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