Sidabutar, Dwi Feris Martua and BUDIJITNO, SELAMAT and Prasetyo, Awal (2021) EFEKTIFITAS MADU MULTIFLORA DALAM MENCEGAH HEPATOTOKSIK PADA PASIEN KANKER PAYUDARA DENGAN KEMOTERAPI FAC 5- FLUROURORACYL, ADRIAMYCIN, DAN CYCLOPHOSPAMIDE. Masters thesis, Universitas Diponegoro.

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Abstract

Background: The combination of FAC (5- fluorouroracyl, adriamycin, and cyclophospamide) is the mostly used breast cancer chemotherapy regiment, which is potentially hepatotoxic. Multiflora honey provides a hepatoprotective effect through phenolic acid and flavonoid compounds, so it can be used as a complementary therapy.
Objective: Analyzing the effectiveness of honey in preventing hepatotoxicity in invasive ductal breast cancer patients receiving FAC chemotherapy
Methods: An experimental study with double blind randomized pre and post test with control group design. 36 patients with ductal invasive breast cancer were randomly divided into 2 groups, the control group receiving FAC chemotherapy (n = 18) and the treatment group receiving chemotherapy and consuming honey 90 ml / day for 14 days (n = 18). The patient's AST, ALT, ALP, and GGT levels were checked before and after 14 days of the study. Characteristic data were performed using Pearson Chi-Square test, data on AST, ALT, ALP, and GGT levels. Normality test with Shapiro-Wilk, pre and post difference test for both groups: Pair t-test
Results: Post-treatment there was reduction and significant differences in AST and ALT levels in the treatment vs control group: AST 33.72±44.35 vs 23.22±4.48 (p=<0.001); ALT were 29.72±16.96 vs 26.06±9.19 (p=0.020). There was increase and significant differences of ALP and GGT levels in the treatment vs control group: ALP 107.00±65.89 vs 103.17±35.30 (p=0.009); GGT were 56.61±58.16 vs 51.33±27.50 (p=0.035).
Conclusion: Giving multiflora honey provides a hepatoprotective effect in patients with invasive ductal breast cancer who are receiving FAC chemotherapy.
Keywords: Multiflora honey, hepatotoxicity,, breast cancer, chemotherapy FAC

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