Fadhila, Alya Nisrina and Muniroh, Muflihatul and Pramono, M. Besari Adi (2024) PENGARUH PAPARAN MERKURI TERHADAP KADAR IL-6, IL-10, IFN-GAMMA, DAN PREEKLAMPSIA DI JAWA TENGAH, INDONESIA. Masters thesis, Universitas Diponegoro.

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Abstract

Objective: This research analyzed the effects of mercury (Hg), Interleukin-6 (IL-6), Interleukin-10 (IL-10), and Interferon-gamma (IFN-gamma) levels on Preeclampsia in pregnant women in Central Java, Indonesia. The analysis was conducted by collecting samples of pregnant women's hair and blood.
Methods: The design of this research was case-control. This research was conducted on 113 pregnant women in Central Java. Data collection was done using questionnaires and medical records. Prenatal exposure of Merkuri was measured from maternal hair samples using mercury analyzer NIC RA-5A. Serum IL-6, IL-10, and IFN-gamma were examined using an ELISA kit. Statistical analysis was done using SPSS.
Results: In this research, maternal hair mercury concentration was classified in the low category with a median of 0.504 (0.039-2.798) ppm. Merkuri concentration in hair was significantly higher among women with preeclampsia than women with normal pregnancy (p < 0.001). Hair mercury concentration is also significantly related to serum IL-10 (p < 0.05). Serum IL-6 and IL-10 were also significantly different between the control and preeclampsia groups. Elevated hair Merkuri concentration was associated with increased preeclampsia risk (OR 20.22; p<0.001; CI 95% 3.77-108.4). Other factors such as level of BMI, smoking exposure, and pollution from factories were significantly associated with preeclampsia (OR 1.14, p<0.05, CI95% 1.01-1,29; OR 7.49, p<0.05, CI95% 1.94-28.85; OR 10.83, p<0.05, CI95% 2.05-57.31) respectively.
Conclusion: This study demonstrates that maternal hair mercury concentration is related to IL-10 and preeclampsia

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