JAABH, MOHAMMED HUSAYN MOHAMMED and HARAHAP, M. SOFYAN and Farida, Helmia (2020) THE EFFECTS OF SEVOFLURANE AND PROPOFOL ON IFN-γ AND IL-12. Masters thesis, Universitas Diponegoro.

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Abstract

Background: This research aimed to analyze the effects of sevoflurane and propofol on IFN-γ and IL-12 study on patients with craniotomy surgery. The treatment is the anesthesia with sevoflurane or propofol for more than 2 hours. The levels of IFN-γ and IL-12 are measured just before induction of anesthesia and just after anesthesia with sevoflurane or propofol is stopped. Methods: The study design is an abservational study by using pre-and post design. The subjects are patients aged 30-55 years old who were undergoing craniotomy surgery for tumor removal at Dr. Kariadi Hospital. The differences in the means before and after the same anaesthesia agent were analyzed with paired T-test if the data distribution is normal, or with the Wilcoxon rank-sum test if the data distribution is not normal. The difference in the means between the two different anaesthesia agents were analyzed using an independent T-test if the data distribution is normal, or with the Mann-Whitney test if the data distribution is not normal. Results: It was observed that sevoflurane and propofol increased the level of IFN-γ and IL-12 but not significant. There were differences between IFN-γ and IL-12 before and after anesthesia with sevoflurane compared with propofol. Therefore, the hypothesis was accepted. This shows that the originality of this research has been statistically and empirically proven. Conclusion: The level of IFN-γ increased significantly after anesthesia with propofol. The level of IL-12 increased after anesthesia with both sevoflurane and Propofol. However, the increase difference between sevoflurane and propofol is not significantly different. Propofol and sevoflurane exerts comparables effect pro-inflammatory response in patients undergoing craniotomy surgery.
Keywords : Effects of sevoflurane, Propofol, IFN- γ, IL12, Craniotomy Surgery

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