Matug, Sumia M. Ali and Prasetyo, Awal and Kisdjamiatun, Kisdjamiatun (2023) THE EFFECT OF Annona muricata TO INCREASE CXCL10 IN THE BRAIN STUDY IN CEREBRAL MALARIA OF SWISS MICE. Masters thesis, Universitas Diponegoro.

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Abstract

BACKGROUND: Malaria is a common and life-threatening disease in many tropical and subtropical areas. A study of cerebral malaria (CM) in children demonstrated that out of 36 biomarkers, only CXCL10 was serum marker independently associated with CM mortality. Objective of this study is to prove that A. muricata may decrease the CXCL10 in Plasmodium berghei ANKA (PbA) inoculated swiss albino mice. METHOD: Study design was experimental study, by used Randomized Post test Only Control Group Design. Thirthy six swiss mices which divided into 6 groups. C(-) is healthy mice, C(+) is group with inoculated PbA, X1 (non inoculated PbA and A. muricata dosage 100 mg/kg BW), X2 (non inoculated PbA and A. muricata dosage 150 mg/kg BW), X3 (inoculated PbA and A. muricata dosage 100 mg/kg BW), X4 (inoculated PbA and A. muricata dosage 150 mg/kg BW). RESULT: Significant difference was found among the studied groups (p=0.003). Positive control group was signiticantly expressed lower CXCL10 than those of healthy groups without or with A. muricata treatment (negative control, p=0.008; X1, p=0.045; or P2, p=0.012). X3 group showed CXCL10 expression comparable with those of healthy mice (negative control, X1 and X2), meanwhile the expression was significantly higher than positive control and X4 groups (p=0.012 and p=0.028, respectively). X4 group showed CXCL10 expression significantly lower than healthy groups which were negative control and P2 groups (p=0.011 and p=0.016, respectively). CONCLUSION: Annona muricata can’t decrease CXCL10 in PbA inoculated swiss albino mice.
Keywords: Annona muricata, P. berghei ANKA, CXCL10

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