NAAMAT, WALID. FARAJ. A. and Kisdjamiatun, Kisdjamiatun and Kristina, Tri Nur (2015) THE EFFECTIVITY OF ANNONA MURICATA TO REDUCE IL-12 LEVEL AND NUMBER OF LEUKOCYTE AND IMPROVE MONOCYTE PERCENTAGE (STUDY IN CEREBRAL MALARIA OF SWISS ALBINO MICE). Masters thesis, Universitas Diponegoro.

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Abstract

BACKGROUND: Many researches were documented through the investigation on ethnopharmalogical use of Annonaceae plants to treat malaria including Annona muricata. This research to prove that Annona muricata treatment reduce IL-12 production and the number of leukocytes and percentage of monocyte during CM phase in Swiss albino mice inoculated with Plasmodium berghei ANKA.
METHOD: Study design was experimental study. 36 swiss mice which devided into 6 groups. K(-) is healthy mice, P1 and P2 were group without inoculated PbA with A. muricata dosage 100 and 150 mg/kg BW. K(+) is group with inoculated PbA, P3 and P4 were group with inoculated PbA and A. muricata dosage 100 and 150 mg/kg BW. Blood was taken from the eyes of mice for leukocyte and monocyte. IL-12 taken from the spleen detected using the ELISA method.
RESULT: Mean of IL-12: K(-): 0.7646; P1: 4.9834; P2: 3.0402; K(+): 3.5989; P3: 3.3647; and P4: 4.9558. Mean number of leukocyte: K(-): 12,550; P1: 9,620; P2: 13,660; K(+): 21,600; P3: 20,483; and P4: 26,433. Mean of monocyte percentage: K(-): 6.33; P1: 5.40; P2: 8.20; K(+): 4.80; P3: 3.50; and P4: 5.50.
CONCLUSION: The extract of A. muricata and PbA inoculation significantly affect the levels of IL-12. The extract of A. muricata and PbA inoculation significantly affect the number of leukocytes. The extract of A. muricata and PbA inoculation significantly affect the percentage of monocytes.
Keywords: Annona muricata, P. berghei ANKA, IL-12, Leukocyte, Monocyte.

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