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EFFECT OF CURCUMA LONGA EXTRACT ON HEPATIC NUCLEUS AND IL-1α AFFECTED BY CIGARETTE SMOKE

ABUAJELAH, MOHAMED and Sarjadi, Sarjadi and Winarto, Winarto (2013) EFFECT OF CURCUMA LONGA EXTRACT ON HEPATIC NUCLEUS AND IL-1α AFFECTED BY CIGARETTE SMOKE. Masters thesis, Universitas Diponegoro.

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Abstract

Background: damage effect of the passive smoking in liver tissue range from liver nucleus changes to liver tissue inflammation, Curcuma longa rhizoma shows anti-inflammatory effect and antioxidant, however there is no literature about its preventive effect. Objective: to identify and analyze the preventive effect of Curcuma longa rhizoma extract on passive smoking induced liver nucleus changes in SD Rats. Methods: This experimental study used randomized post-test only control group design in 12 SD Rats given 5 cigar as passive cigarette smoking with 50 minute as interval time between each cigarette daily for 13 weeks (group A), 13 weeks (group B) + oral Curcuma longa rhizoma extract with dose 80mg/.kg,B.W, after got passive smoke daily ,The liver nucleus change were HE stained and observed for liver nucleus changes ,and immunohistochemistry was undertaken to count the percentage of IL.1α stained according to Allred Score. Result: the difference among group liver nucleus changes (A & B) were statistically significant (p=0.003). and between groups IL.1-α (A&B) statistically significant (p=0.007), preventive effect for the liver nucleus changes ,the difference of IL.1α expression among groups statistically significant (p= t (p=<0.05) . Conclusion: there was preventive effect on liver nucleus changes in groups with Curcuma longa rhizoma extract and also there was preventive effect on the IL.1 expression with Curcuma longa rhizoma.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Curcuma longa rhizoma extract ,cigarette smoking , liver nucleus changes , IL.1 expression.
Subjects: Medicine
Divisions: Faculty of Medicine > Master Program in Biomedical Science
Depositing User: heni lutfiatun
Date Deposited: 31 Jan 2023 08:42
Last Modified: 31 Jan 2023 08:42
URI: https://eprints2.undip.ac.id/id/eprint/11556

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